ProSight Native

Our latest software for native top-down mass spectrometry that includes analysis workflows for complexes and large intact proteins.

 

Simplify complexity. 

Unveil the full composition and stoichiometry of a protein complex using ProSight Native’s unique workflow to analyze each level of a complex-down mass spectrometry experiment:

  1. Intact complex mass analysis

  2. Subunit mass analysis

  3. Subunit fragmentation analysis.

ProSight Native is currently the only software available that can perform all 3 analysis components.

 
 

Test ProSight Native

To receive a free 60-day demo license or purchase a subscription, please contact us.

 

Determine.

  • Assess protein complex and subunit masses with mass deconvolution algorithms. ProSight Native integrates our flagship ProSight database search engine, allowing you to then elucidate subunit proteoform identities.

  • Automatically compile data to yield the full stoichiometry of subunits and even non-covalently-bound ligands associated with the complex.

Deconvolute.

  • Determine masses for isotopically-resolved and -unresolved proteins. ProSight Native combines kDecon and THRASH deconvolution for analyzing proteins of any size.

Search.

  • Search native proteoform fragmentation data against candidate proteoforms using ProSight search. Candidates are composed of evidence-backed, site-specific post-translational modifications from UniProt XML files.